Sirolimus;Temsirolimus/Selected Calcium Channel Blockers Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not be able to process sirolimus, temsirolimus, or verapamil properly.
What might happen:
Your blood levels of sirolimus may increase and cause toxic effects. If you are taking verapamil, the amount of verapamil in your blood may increase and lower your blood pressure too much.
What you should do about this interaction:
Contact your doctor if you experience a decrease in the amount of urine you make, if you develop any new side effects from your medicine, or if have any dizziness or fainting episodes.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, it may be necessary to adjust the dose of tacrolimus or change you to a different medicine. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Rapamune (sirolimus) US prescribing information. Wyeth Pharmaceuticals Aug, 2022.
- 2.Bottiger Y, Sawe J, Brattstrom C, Tollemar J, Burke JT, Hass G, Zimmerman JJ. Pharmacokinetic interaction between single oral doses of diltiazem and sirolimus in healthy volunteers. Clin Pharmacol Ther 2001 Jan;69(1):32-40.
- 3.Torisel (temsirolimus) US prescribing information. Wyeth Pharmaceuticals, Inc. March, 2018.
- 4.Fyarro (sirolimus protein-bound particles for injectable susspension) US prescribing information. Aadi Bioscience, Inc. November, 2021.
- 5.Covera-HS (verapamil hydrochloride) US prescribing information. G.D. Searle LLC September, 2017.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.