Hydantoins/Fluvoxamine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, fluvoxamine may prevent your body from processing your seizure medicine properly.
What might happen:
The blood levels of your seizure medicine may increase and cause toxic effects.
What you should do about this interaction:
Make sure all of your doctors and other healthcare professionals (e.g. pharmacist) know that you are taking these medicines together.It may be necessary to measure the blood levels of your seizure medicine more often or adjust the dose to make sure you are at safe and effective level.If you develop the onset of nausea, vomiting, loss of coordination or trouble walking, confusion, dizziness, seizures, unusual eye movements, double vision or the onset of other severe symptoms, contact your doctor.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Dilantin (phenytoin sodium) US prescribing information. Pfizer, Inc. March, 2022.
- 2.Luvox (fluvoxamine maleate) US prescribing information. Jazz Pharmaceuticals, Inc. August, 2023.
- 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 4.Mamiya K, Kojima K, Yukawa E, Higuchi S, Ieiri I, Ninomiya H, Tashiro N. Phenytoin intoxication induced by fluvoxamine..
- 5.Jalil P. Toxic reaction following the combined administration of fluoxetine and phenytoin: two case reports. J Neurol Neurosurg Psychiatry 1992 May;55(5):412-3.
- 6.Woods DJ, Coulter DM, Pillans P. Interaction of phenytoin and fluoxetine. N Z Med J 1994 Jan 26;107(970):19.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.