Triamterene; Amiloride/Selected NSAIDs; Salicylates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. When these two medicines are taken together, your nonsteroidal anti-inflammatory medicine may increase the effects of your water pill on the kidney.

What might happen:

You may experience kidney failure or an increase in your blood levels of potassium.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, it may be necessary to check your kidney function and potassium levels more often. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Favre L, Glasson P, Riondel A, Vallotton MB. Interaction of diuretics and non-steroidal anti-inflammatory drugs in man. Clin Sci (Lond) 1983 Apr; 64(4):407-15.
  • 2.Lodine (etodolac) US prescribing information. Wyeth Pharmaceuticals March, 2006.
  • 3.Nalfon (fenoprofen) US prescribing information. Dista May, 2016.
  • 4.Oruvail (ketoprofen) US prescribing information. Wyeth-Ayerst Laboratories March, 2006.
  • 5.Toradol (ketorolac tromethamine) US prescribing information. Roche Pharmaceuticals March, 2013.
  • 6.Ponstel (mefenamic acid) US prescribing information. Parke-Davis May, 2016.
  • 7.Relafen (nabumetone) US prescribing information. GlaxoSmithKline February, 2006.
  • 8.Daypro (oxaprozin) US prescribing information. Pfizer May, 2021.
  • 9.Clinoril (sulindac) US prescribing information. Merck & Co., Inc. December, 2010.
  • 10.Tolectin (tolmetin) US prescribing information. Teva Pharmaceuticals June, 2006.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.