Tranexamic Acid; Aminocaproic Acid; Aprotinin/Tretinoin, Oral Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines can increase your risk of a blood clot.
What might happen:
Using these medicines together may increase your risk of forming an unwanted blood clot.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Get medical help right away if you experience: sudden shortness of breath, chest/jaw/left arm pain, unusual sweating, confusion, coughing up blood, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, tingling/weakness/numbness in the arms/legs, unusual headaches (including headaches with vision changes/lack of coordination, worsening of migraines, sudden/very severe headaches), slurred speech, weakness on one side of the body, sudden vision changes (such as partial/complete blindness).Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Lysteda (tranexamic acid) US prescribing information. Ferring Pharmaceuticals, Inc. October, 2013.
- 2.Hashimoto S, Koike T, Tatewaki W, Seki Y, Sato N, Azegami T, Tsukada N, Takahashi H, Kimura H, Ueno M, et al. Fatal thromboembolism in acute promyelocytic leukemia during all-trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage. Leukemia 1994 Jul;8(7):1113-5.
- 3.Kocak U, Gursel T, Ozturk G, Kantarci S. Thrombosis during all-trans-retinoic acid therapy in a child with acute promyelocytic leukemia and factor VQ 506 mutation. Pediatr Hematol Oncol 2000 Mar; 17(2):177-80.
- 4.Mahendra P, Keeling DM, Hood IM, Baglin TP, Marcus RE. Fatal thromboembolism in acute promyelocytic leukaemia treated with a combination of all-trans retinoic acid and aprotonin. Clin Lab Haematol 1996 Mar;18(1):51-2.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.