Clozapine/Ciprofloxacin Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Ciprofloxacin may slow down how quickly your liver processes clozapine. Both medications can affect your heart's rhythm.
What might happen:
The amount of clozapine in your blood may increase and cause more side effects, such as a fast heartbeat, weakness, fatigue, dizziness, increased salivation, or decreased breathing. You may also experience a change in your heart rhythm, which may increase your risk of irregular heartbeat, which may be life-threatening.
What you should do about this interaction:
If you notice an increase in side effects, notify your healthcare professionals (e.g. doctor or pharmacist). Your doctor may want to change the dose of your clozapine while you are taking ciprofloxacin, or your doctor may want to change your antibiotic. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.