Cerivastatin/Fibrates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medications can cause muscle pain, which may be worse if taken together. Fibrates may stop the body from being able to break down cerivastatin which could increase cerivastatin levels and may lead to muscle pain.

What might happen:

You may experience an increased risk of severe muscle pain, flu-like symptoms, and sudden decrease in the amount of urine.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. Let your doctor know if you have a history of kidney problems, which may make this interaction worse. Tell your doctor right away if you experience muscle pain, tenderness, or weakness; unexplained tiredness; a change in the amount of urine you make; and/or discolored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference
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  • 2.Lopid (gemfibrozil) US prescribing information. Pfizer Pharmaceuticals, Ltd. November, 2014.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.