Haloperidol/Natisedine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process the medicines differently. Both of your medicines may affect your heart's rhythm, and may cause more side effects when used together.

What might happen:

The effects of your natisedine may increase and cause increased drowsiness, slowed breathing, and a decrease in blood pressure. The effects of your haloperidol may decrease and it may not work as well. Taking haloperidol with natisedine can affect your heart rhythm and may increase your risk of an irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

If you experience excessive drowsiness, slowed breathing, weakness, fatigue, or dizziness, contact your doctor. It may be necessary to monitor your blood pressure and breathing rate. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Let your doctor know if your symptoms worsen. Your doctor may need to adjust the dose of your medicines.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 2.Dozic (haloperidol) UK summary of product characteristics. Rosemont Pharmaceuticals Limited September 10, 2007.
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  • 4.USDepartment of Health and Human Services Food and Drug Administration. ICH E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs. Available at: https://www.fda.gov/media/71372/download October, 2005.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.