Haloperidol/Strong CYP3A4 Inducers that Prolong QT Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may speed up how quickly your liver processes your haloperidol. Both of your medicines can affect your heart's rhythm.

What might happen:

The amount of haloperidol in your blood may decrease and it may not work as well. Taking your haloperidol with other medicines that can affect your heart rhythm may increase your risk of irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and if you notice any change in your condition. Your doctor may want to change or adjust the dose of one of your medicines.Your doctor may want to monitor a test called an electrocardiogram (ECG) while you are taking haloperidol to see if it is affecting your heart's rhythm. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference
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