Who should not take Protriptyline HCL?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • overactive thyroid gland
  • dementia
  • schizophrenia
  • manic-depression
  • suicidal thoughts
  • alcohol use disorder
  • increased pressure in the eye
  • closed angle glaucoma
  • heart attack within the last 30 days
  • coronary artery disease
  • abnormal heart rhythm
  • low blood pressure
  • asthma
  • gastroesophageal reflux disease
  • hiatal hernia
  • liver problems
  • enlarged prostate
  • electroshock therapy
  • recent operation
  • seizures
  • an inability to completely empty the bladder
  • chronic idiopathic constipation
  • CYP2D6 poor metabolizer
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye


  • Tricyclic Antidepressants and Tricyclic Compounds

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.