Selected Nephrotoxic Agents/Cisplatin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The toxic effects of cisplatin in addition to your antibiotics or non-steriodal anti-inflammatory drugs (NSAIDs) may be additive.

What might happen:

You may experience nausea, vomiting, rash, itching, a change in hearing, or numbness.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) right away about taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicines before checking with them first.

  • 1.Amikacin sulfate injection US prescribing information. Heritage Pharmaceuticals, Inc. June, 2020.
  • 2.Cisplatin injection US prescribing information. WG Critical Care February, 2019.
  • 3.Gentamicin injection B.P. Australian prescribing information. Pharmacia September, 2002.
  • 4.Gentamicin injection UK summary of product characteristics. Mayne Pharma Plc February, 2004.
  • 5.Gentamicin injection US prescribing information,. Fresenius Kabi USA, LLC. October, 2015,.
  • 6.Tobramycin US prescribing information. X-GEN Pharmaceuticals, Inc. September, 2011.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.