Aldosterone Receptor Antagonists/NSAIDs; Salicylates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. When these two medicines are taken together, your nonsteroidal anti-inflammatory medicine may increase the effects of your blood pressure/water pill on the kidney.

What might happen:

You may experience kidney failure or an increase in your blood levels of potassium.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. It may be necessary to check your kidney function and potassium levels within 1 week of starting and more often when taking a nonsteroidal anti-inflammatory medicine. It may be necessary to change your pain medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Inspra (eplerenone) US prescribing information. Pfizer, Inc. May, 2018.
  • 2.Aldactone (spironolactone) US prescribing information. Pfizer December, 2022.
  • 3.KERENDIA (finerenone) US prescribing information. Bayer HealthCare Pharmaceuticals Inc. July, 2021.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.