Itraconazole; Ketoconazole/Nevirapine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nevirapine increases how quickly your body processes your antifungal medicine. Ketoconazole may decrease how quickly your body processes nevirapine.
What might happen:
When taken together, nevirapine may decrease the levels of antifungal medicine in your blood, making it less effective. Ketoconazole may increase the amount of nevirapine in your blood.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine, adjust the dose or check medicine levels in your blood.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Viramune (nevirapine) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. June, 2022.
- 2.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
- 3.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. February, 2024.
- 4.Department of Health and Human Services. Table 15b. Drug Interactions between Non-Nucleoside Reverse Transcriptase Inhibitors and Other Drugs. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents 02/12/2013.
- 5.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.