Propranolol/Zileuton Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Zileuton may slow down how quickly your liver processes your heart medicine.
What might happen:
An increase in the beneficial and side effects of your heart medicine may occur.
What you should do about this interaction:
Let your health care professionals (e.g. doctor or pharmacist) know that you are taking these medicine together or if you stop taking zileuton. If you experience a slow heart rate, weakness, fatigue, or dizziness, contact your doctor. Your doctor may need to adjust the dose of your heart medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Lu P, Schrag ML, Slaughter DE, Raab CE, Shou M, Rodrigues AD. Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos 2003 Nov; 31(11):1352-60.
- 2.Zyflo (zileuton) US prescribing information. Cornerstone Therapeutics, Inc. November, 2011.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.