Quinolones, Oral/Didanosine Pediatric Solution & Antacid Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When the pharmacist prepares your didanosine pediatric suspension, he/she mixes the solution with an antacid that contains aluminum and magnesium hydroxide. The aluminum and magnesium 'cations' in the suspension may bind to the antibiotic. This prevents your body from absorbing the antibiotic.

What might happen:

The blood levels of your antibiotic may be decreased, which will decrease its effectiveness in treating your infection.

What you should do about this interaction:

You should time when you take your antibiotic and your didanosine pediatric suspension, which contains aluminum and magnesium, so that you do not take: ---ciprofloxacin for at least 2 hours before or 6 hours after your didanosine suspension. ---delafloxacin for at least 2 hours before or 6 hours after your didanosine suspension. ---enoxacin for at least 2 hours before or 8 hours after your didanosine suspension. ---gatifloxacin for at least 4 hours before oral cations. ---gemifloxacin for at least 2 hours before or 3 ours after oral cations. ---lomefloxacin for at least 2 hours before or 4 hours after oral cations. ---moxifloxacin for at least 4 hours before or 8 hours after oral cations ---nalidixic acid for at least 2 hours before or 2 hours after your didanosine suspension. ---norfloxacin for at least 2 hours before or 2 hours after your didanosine suspension. ---ofloxacin for at least 2 hours before or 2 hours after your didanosine suspension. ---sparfloxacin for at least 4 hours before your didanosine suspension. ---trovafloxacin for at least 2 hours before or after oral cations. ---prulifloxacin for at least 2 hours before or 4 hours after oral cations. If you are not sure which antibiotic you are on or if you have questions about the timing of doses of your medicine, contact your healthcare professionals (e.g. doctor or pharmacist). They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.