Selected Vinca Alkaloids/Slt Azole Antifungal; Levoketoconazole Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some azole antifungal medicines may slow down how quickly your liver processes vinca alkaloids. Levoketoconazole may slow down how quickly your liver processes vinca alkaloids.

What might happen:

The levels of vinca alkaloids in your blood may increase and you may experience more chemotherapy-related toxicity than normally expected.

What you should do about this interaction:

Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together, or if you have recently (in the past few weeks) undergone chemotherapy with a vinca alkaloid. Your doctor may need to monitor you more closely. Let your doctor know right away if you have any muscle weakness, numbness or loss of feeling, abdominal pain, constipation, seizures, or swelling, or if any side effects are worse than in previous chemotherapy cycles.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference
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  • 2.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. January, 2022.
  • 3.Noxafil (posaconazole) US prescribing information. Merck & Co. Inc January, 2022.
  • 4.Vfend (voriconazole) US prescribing information. Pfizer Inc. October, 2022.
  • 5.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
  • 6.Javlor (vinflunine ditartrate) UK Summary of Product Characteristics. Pierre Fabre Limited September 21, 2009.
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  • 13.Eiden C, Palenzuela G, Hillaire-Buys D, Margueritte G, Cociglio M, Hansel-Esteller S, Peyriere H. Posaconazole-increased vincristine neurotoxicity in a child: a case report. J Pediatr Hematol Oncol 2009 Apr;31(4):292-5.
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  • 15.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. February, 2024.
  • 16.Recorlev (levoketoconazole) US prescribing information. Xeris Pharmaceuticals, Inc. June, 2023.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.