Atazanavir/H2 Antagonists Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
H-2 antagonists increase the pH (decrease the acidity) of your stomach. Atazanavir needs an acidic environment to be absorbed by your body.
What might happen:
The amount of atazanavir in your blood may decrease and it may not work as well against your HIV infection.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Discuss with your healthcare professional how you should take these medicines. Your doctor may want you to separate their administration times or may want to change the dose of your medicines. Your doctor may want to change your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Reyataz (atazanavir sulfate) Australian product information. Bristol-Myers Squibb Pharmaceuticals January 8, 2004.
- 2.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company September, 2020.
- 3.Tybost (cobicistat) US prescribing information. Gilead Sciences, Inc. September, 2021.
- 4.Evotaz (atazanavir and cobicistat) US prescribing information. Bristol-Myers-Squibb Company May, 2023.
- 5.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents Living with HIV. Department of Health and Human Services. Available at https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv/whats- new-guidelines June 13, 2021.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.