Dasatinib; Pazopanib/H2 Antagonists Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The pH of your GI tract needs to be acidic for your cancer medicine to dissolve and be absorbed. H2 antagonists change the pH (acidity) in your GI tract.
What might happen:
The amount of cancer medicine in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may instruct you to take antacids instead of your H2 blocker.If you need to use an antacid while on dasatinib, take the antacid at least 2 hours before or 2 hours after your dasatinib.If you need to use an antacid while on pazopanib, take the antacid at several hours before or after your pazopanib.If you have questions about how to schedule your medicines, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Sprycel (dasatinib) US prescribing information. Bristol-Myers Squibb Company February, 2023.
- 2.Votrient (pazopanib) US prescribing information. GlaxoSmithKline October, 2009.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.