Aripiprazole/Duloxetine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Duloxetine may slow down how quickly your liver processes aripiprazole.
What might happen:
The amount of aripiprazole in your blood may increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and any other medicines you are taking. Your doctor may want to change the dose of your aripiprazole while you are taking duloxetine. Let your doctor know if you notice an increase in side effects while taking these medicines together, especially any muscle stiffness, confusion, rapid or irregular heartbeat, sweating, involuntary movements, dizziness or fainting when getting up from a seated or lying position, or excessive sleepiness.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Abilify (aripiprazole) US prescribing information. Otsuka America Pharmaceutical, Inc. August, 2019.
- 2.Schwartz T Raza S. Aripiprazole (Abilify) and Tardive Dyskinesia. P&T January, 2008;33(1):32-34.
- 3.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
- 4.Abilify Maintena (aripiprazole ext-rel inj.) prescribing information. Otsuka Pharmaceuticals January, 2016.
- 5.Margraff T, Schoretsanitis G, Neuner I, Haen E, Gaebler AJ, Paulzen M. Discovering interactions in augmentation strategies: Impact of duloxetine on the metabolism of aripiprazole. Basic Clin Pharmacol Toxicol 2023 Jul; 133(1):73-81.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.