Aripiprazole/Bupropion Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Bupropion may slow down how quickly your liver processes aripiprazole. Both bupropion and aripiprazole may make you more susceptible to having a seizure.
What might happen:
The amount of aripiprazole in your blood may increase and cause more side effects than normal. There is also an increased risk that you may have a seizure while taking these medicines together.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your aripiprazole while you are taking bupropion. Let your doctor know if you notice an increase in side effects while taking these medicines together, especially any restlessness, muscle or joint stiffness, confusion, sweating, involuntary movements, dizziness or fainting when getting up from a seated or lying position, or have nausea or vomiting. If you have or think you have had a seizure, get medical attention right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Abilify (aripiprazole) US prescribing information. Otsuka America Pharmaceutical, Inc. August, 2019.
- 2.Abilify Maintena (aripiprazole ext-rel inj.) prescribing information. Otsuka Pharmaceuticals January, 2016.
- 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 4.Wellbutrin (bupropion hydrochloride) US prescribing information. GlaxoSmithKline November, 2019.
- 5.Zyban (bupropion hydrochloride) US prescribing information. GlaxoSmithKline July, 2019.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.