Tizanidine/Osilodrostat Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Osilodrostat can slow down how quickly your liver breaks down tizanidine.
What might happen:
The amount of tizanidine in your blood may increase and cause more side effects than normal, including severe low blood pressure, drowsiness, and decreased ability to move your body.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and all other medicines you are taking.Your doctor may want to change the dose of your tizanidine. Use caution when performing tasks that require alertness.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Isturisa (osilodrostat) US prescribing information. Recordati Rare Diseases, Inc. March, 2020.
- 2.Zanaflex (tizanidine hydrochloride) US prescribing information. Acordia Therapeutics, Inc. November 7, 2013.
- 3.American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2023 Jul;71(7):2052-2081.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.