Paliperidone; Quetiapine/Strong CYP3A4 Inducers that Prolong QT Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your medicines may speed up how quickly your liver processes paliperidone and quetiapine. In addition your medicines can affect your heart's rhythm.
What might happen:
The amount of paliperidone and quetiapine in your body may decrease and they may not work as well. Taking your cancer medicine with other medicines that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may change your medicines. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Invega Sustenna (paliperidone palmitate) US prescribing information. Janssen Pharmaceuticals, Inc. December 20, 2017.
- 2.Invega Trinza (paliperidone palmitate) US prescribing information. Janssen Pharmaceuticals, Inc. August, 2021.
- 3.Invega Hafyera (paliperidone palmitate) US prescribing information. Janssen Pharmaceuticals, Inc October, 2021.
- 4.Seroquel (quetiapine) US prescribing information. AstraZeneca Pharmaceuticals LP September, 2020.
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- 11.Yasui-Furukori N, Kubo K, Ishioka M, Tsuchimine S, Inoue Y. Interaction between paliperidone and carbamazepine. Ther Drug Monit 2013 Oct; 35(5):649-52.
- 12.USDepartment of Health and Human Services Food and Drug Administration. ICH E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs. Available at: https://www.fda.gov/media/71372/download October, 2005.
- 13.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.