Oral Iron Supplements/Antacids and Selected Minerals Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some antacids and minerals may bind to your iron supplement, preventing it from being absorbed.Some vitamins may contain "hidden" antacids such as some forms of calcium and magnesium.
What might happen:
The amount of iron you absorb from your supplement may decrease.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Do not take your iron supplement within 1 hour before or 2 hours after your antacid. Your doctor may want to check your iron levels to see if your supplement is working.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Ferrous gluconate US prescribing information. GFR Nutritionals Ltd September 29, 2003.
- 2.Wallace KL, Curry SC, LoVecchio F, Raschke RA. Effect of magnesium hydroxide on iron absorption following simulated mild iron overdose in human subjects. Acad Emerg Med 1998 Oct;5(10):961-5.
- 3.O'Neil-Cutting MA, Crosby WH. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986 Mar 21;255(11):1468-70.
- 4.Snyder BK, Clark RF. Effect of magnesium hydroxide administration on iron absorption after a supratherapeutic dose of ferrous sulfate in human volunteers: a randomized controlled trial. Ann Emerg Med 1999 Apr; 33(4):400-5.
- 5.Hall GJ, Davis AE. Inhibition of iron absorption by magnesium trisilicate. Med J Aust 1969 Jul 12;2(2):95-6.
- 6.Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorption. Am J Clin Nutr 1991 Jan;53(1):106-11.
- 7.Pruchnicki MC, Coyle JD, Hoshaw-Woodard S, Bay WH. Effect of phosphate binders on supplemental iron absorption in healthy subjects. J Clin Pharmacol 2002 Oct;42(10):1171-6.
- 8.Rossander-Hulten L, Brune M, Sandstrom B, Lonnerdal B, Hallberg L. Competitive inhibition of iron absorption by manganese and zinc in humans. Am J Clin Nutr 1991 Jul;54(1):152-6.
- 9.Valberg LS, Flanagan PR, Chamberlain MJ. Effects of iron, tin, and copper on zinc absorption in humans. Am J Clin Nutr 1984 Sep;40(3):536-41.
- 10.Solomons NW, Jacob RA. Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc. Am J Clin Nutr 1981 Apr;34(4):475-82.
- 11.Friel JK, Serfass RE, Fennessey PV, Miller LV, Andrews WL, Simmons BS, Downton GF, Kwa PG. Elevated intakes of zinc in infant formulas do not interfere with iron absorption in premature infants. J Pediatr Gastroenterol Nutr 1998 Sep;27(3):312-6.
- 12.Phansalkar S, van der Sijs H, Tucker AD, Desai AA, Bell DS, Teich JM, Middleton B, Bates DW. Drug-drug interactions that should be non-interruptive in order to reduce alert fatigue in electronic health records. J Am Med Inform Assoc 2012 Sep 25.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.