Entacapone/Oral Iron Supplements Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medications are taken together, they may bind together in your stomach. Entacapone may bind to your iron supplement, preventing it from being absorbed. Some multivitamins may contain iron and can be affected as well.

What might happen:

The amount of entacapone and iron you absorb into your body may decrease.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Do not take your iron supplement within 2-3 hours before or after entacapone. Your doctor may want to check your iron levels to see if your supplement is working.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Entacapone UK summary of prescribing characteristics. Mylan Pharmaceuticals Inc. December, 2017.
  • 2.Comtan (entacapone) US prescribing information. Orion Corporation February, 2016.
  • 3.Stalveo (carbidopa; entacapone; levodopa) US Prescribing Information. Orion/Novartis December, 2019.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.