Ergot Alkaloids/Sympathomimetics Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are given together, the effects of one or both may increase.

What might happen:

You may experience an increase in blood pressure and reduced blood flow to your organs and hands/feet.

What you should do about this interaction:

Make sure your healthcare professionals know all the medicines you are taking. They may already be aware of this interaction and may be monitoring you for it. If you experience increased blood pressure; chest pain; change in heartbeat; numbness and tingling of your hands, feet, or face; pain in your arms, legs, or lower back; itching; or other symptoms while taking these medicines together, contact your doctor right away. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Buchanan N, Cane RD, Miller M. Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration. Intensive Care Med 1977 Aug;3(2):55-6.
  • 2.Barthel W, Glusa E, Koth W. Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ. Int J Clin Pharmacol Ther Toxicol 1987 Feb;25(2):63-9.
  • 3.Chuang SS. Finger ischemia secondary to the synergistic agonist effect of norepinephrine and ergonovine and in a burn patient. Burns 2003 Feb; 29(1):92-4.
  • 4.D. H. E. 45 (dihydroergotamine mesylate) US prescribing information. Valeant Pharmaceuticals North America November 6, 2017.
  • 5.Cafergot (ergotamine tartrate and caffeine) tablets US prescribing information. Sandoz Inc May 14, 2012.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.