Alprostadil/Acetaminophen; NSAIDs Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Acetaminophen and NSAIDs may interfere with how alprostadil works in the body.

What might happen:

Alprostadil may not work as well.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Prostin VR Pediatric (alprostadil injection) US prescribing information. Pharmacia and Upjohn Company LLC May, 2020.
  • 2.Schindler T, Smyth J, Bolisetty S, Michalowski J, Mallitt KA, Singla A, Lui K. Early PARacetamol (EPAR) Trial: A Randomized Controlled Trial of Early Paracetamol to Promote Closure of the Ductus Arteriosus in Preterm Infants. Neonatology 2021;118(3):274-281.
  • 3.Bahrami R, Ezzatabadi A, Mehdizadegan N, Mohammadi H, Amoozgar H, Edraki M. Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?. Ital J Pediatr 2021 Feb 18;47(1):37.
  • 4.Luecke CM, Liviskie CJ, Zeller BN, Vesoulis ZA, McPherson C. Acetaminophen for Patent Ductus Arteriosus in Extremely Low-Birth-Weight Neonates. J Pediatr Pharmacol Ther 2017 Nov-Dec;22(6):461-466.
  • 5.Jennifer MRyder PharmD; Esther Bae PharmD. Increasing Alprostadil Requirements in a Neonate With Cardiac Anomalies and Co-administration of Rectal and Oral Acetaminophen. J Pediatr Pharmacol Ther 2022 Aug 19; 27(6):573-7.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.