What should I Know Regarding Pregnancy, Nursing and Administering Z-Tuss AC to Children or the Elderly?

If you are PREGNANT

  • Requires a Risk/Benefit Assessment:
  • Requires a Risk/Benefit Assessment:

If you are NURSING

  • Precaution: RESP DEP POSS IN INFANT,NON-OPIOID ALT REC, OR USE LOW DOSE SHORTEST DURATION
  • Precaution: INSUFFICIENT DATA AVAILABLE; MAY CAUSE SEDATION AND INHIBIT LACTATION

If you are an adult over 60

  • Management or Monitoring Precaution: General-Consider adding naloxone Rx. Pulmonary-Life threatening respiratory depression risk with high doses, cachexia, or debilitation due to altered pharmacokinetics (poor fat stores, muscle wasting, or altered clearance). Monitor closely at initiation and dose titration. Neuro/Psych-Risk for increased confusion and delirium. May increase fall risk. Avoid treatment with 3 or more CNS active drugs. Gastrointestinal-Constipation risk. Urogenital-Urinary retention risk.
  • Management or Monitoring Precaution: Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.

Giving Z-Tuss AC to a child under 12

  • Severe Precaution: Risk of CNS depression and paradoxical excitation. Consult healthcare provider for age< 6 years.
  • Contraindication: Possible paradoxical CNS excitation. Seizure risk in newborns.
  • Contraindication: Not indicated for symptoms of cough and cold in pediatrics. Risk of slowed or difficult breathing and respiratory depression. Death reported in CYP2D6 ultra-rapid metabolizers post tonsillectomy or adenoidectomy.
  • Contraindication: Risk of serious and life-threatening adverse effects of CNS depression or excitation. Not recommended age <2 years. Avoid using with underlying asthma.
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