Risperidone Intramuscular Monthly/Bupropion Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Bupropion may slow down how quickly your liver processes risperidone. Both bupropion and risperidone may make you more susceptible to having a seizure.
What might happen:
The amount of risperidone in your blood may increase and cause more side effects than normal. There is also an increased risk that you may have a seizure while taking these medicines together.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicines. Let your doctor know if you notice an increase in side effects while taking these medicines together, especially any restlessness, muscle or joint stiffness, confusion, sweating, involuntary movements, dizziness or fainting when getting up from a seated or lying position, or have nausea or vomiting. If you have or think you have had a seizure, get medical attention right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Wellbutrin (bupropion hydrochloride) US prescribing information. GlaxoSmithKline November, 2019.
- 2.Zyban (bupropion hydrochloride) US prescribing information. GlaxoSmithKline July, 2019.
- 3.Risvan (risperidone) US prescribing information. Laboratorios Farmaceuticos Rovi S.A. Madrid, Spain March, 2024.
- 4.Spina E, Avenoso A, Scordo MG, Ancione M, Madia A, Gatti G, Perucca E. Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction. J Clin Psychopharmacol 2002 Aug;22(4):419-23.
- 5.Bondolfi G, Eap CB, Bertschy G, Zullino D, Vermeulen A, Baumann P. The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychiatric patients. Pharmacopsychiatry 2002 Mar;35(2):50-6.
- 6.Spina E, Avenoso A, Facciola G, Scordo MG, Ancione M, Madia A. Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine. Ther Drug Monit 2001 Jun;23(3):223-7.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.