Selected NSAIDs/Probenecid Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Probenecid may slow down the removal of NSAIDs from your body.
What might happen:
The level of the NSAID in your body may go increase and can increase your chance of having side effects from your medicine, such as blurred vision, drowsiness, or kidney problems.
What you should do about this interaction:
Inform your healthcare provider if you are taking any NSAIDs, such as indomethacin or naproxen. If you experience any side effects from your NSAID, inform your doctor immediately. Your doctor may want to change the dose of your medicine or for you to stop taking one of your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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- 2.Skeith MD, Simkin PA, Healey LA. The renal excretion of indomethacin and its inhibition by probenecid. Clin Pharmacol Ther 1968 Jan-Feb;9(1):89-93.
- 3.Upton RA, Williams RL, Buskin JN, Jones RM. Effects of probenecid on ketoprofen kinetics. Clin Pharmacol Ther 1982 Jun;31(6):705-12.
- 4.Wollheim FA, Stenberg P, Nilsson B, Mellbin G. Clinical and methodological studies on intramuscular ketoprofen in postoperative rheumatic pain. Eur J Clin Pharmacol 1981;20(6):423-5.
- 5.Runkel R, Mroszczak E, Chaplin M, Sevelius H, Segre E. Naproxen-probenecid interaction. Clin Pharmacol Ther 1978 Dec;24(6):706-13.
- 6.Day RO, Geisslinger G, Paull P, Williams KM. Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers. Br J Clin Pharmacol 1994 Jan;37(1):79-81.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.