Elbasvir-Grazoprevir/OATP1B1-3 Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your other medicine may increase the amount of elbasvir-grazoprevir in your body.
What might happen:
You may have more side effects from elbasvir-grazoprevir than usual, including liver toxicity.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine.Let your doctor know right away if you have severe nausea, fatigue, yellowing of your skin or eyes, abdominal pain, or dark urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Zepatier (elbasvir-grazoprevir) US prescribing information. Merck & Co., Inc. December, 2019.
- 2.Zepatier (elbasvir-grazoprevir) Canadian product monograph. Merck Canada Inc. January 19, 2016.
- 3.Rukobia (fostemsavir) US prescribing information. ViiV Healthcare July, 2020.
- 4.Prezista (darunavir) US prescribing information. Janssen Therapeutics March, 2023.
- 5.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company November, 2023.
- 6.Paxlovid (nirmatrelvir tablets and ritonavir tablets) US prescribing information. Pfizer Inc. May, 2023.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.