Selected Immunosuppressants/Maribavir Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Maribavir may may slow down how quickly your body processes cyclosporine, everolimus, sirolimus, tacrolimus and temsirolimus.
What might happen:
Your blood levels of cyclosporine, everolimus, sirolimus, tacrolimus or temsirolimus may increase and cause toxic effects that may harm your kidneys.
What you should do about this interaction:
Make sure that your doctor knows all of the medicines that you are taking.Tell your doctor if you have any kidney problems. If you experience any shortness of breath, unusual swelling, changes in the color or amount of your urine, or changes in how often you urinate, contact your doctor.The amount of cyclosporine, everolimus, sirolimus, tacrolimus, or temsirolimus in your blood may need to be checked more often and the dosage adjusted when you first start or stop taking maribavir.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Torisel (temsirolimus) US prescribing information. Wyeth Pharmaceuticals, Inc. March, 2018.
- 2.Fyarro (sirolimus protein-bound particles for injectable susspension) US prescribing information. Aadi Bioscience, Inc. November, 2021.
- 3.Rapamune (sirolimus) US prescribing information. Wyeth Pharmaceuticals Aug, 2022.
- 4.Livtencity (maribavir) US prescribing information. Takeda Pharmaceuticals America, Inc. November, 2021.
- 5.Ferguson RM, Sutherland DE, Simmons RL, Najarian JS. Ketoconazole, cyclosporin metabolism, and renal transplantation. Lancet 1982 Oct 16; 2(8303):882-3.
- 6.Daneshmend TK. Ketoconazole-cyclosporin interaction. Lancet 1982 Dec 11; 2(8311):1342-3.
- 7.Smith JM, Hows JM, Gordon-Smith EC, Baughan A, Goldman JM. Interaction of CyA and ketoconazole. Clin Sci 1983;64(2):67P.
- 8.Shepard JH, Canafax DM, Simmons RL, Najarian JS. Cyclosporine-ketoconazole: a potentially dangerous drug-drug interaction. Clin Pharm 1986 Jun;5(6):468.
- 9.Daneshmend TK, Warnock DW. Clinical pharmacokinetics of ketoconazole. Clin Pharmacokinet 1988 Jan;14(1):13-34.
- 10.Charles BG, Ravenscroft PJ, Rigby RJ. The ketoconazole-cyclosporin interaction in an elderly renal transplant patient. Aust N Z J Med 1989 Jun;19(3):292-3.
- 11.Baciewicz AM, Baciewicz FA Jr. Cyclosporine pharmacokinetic drug interactions. Am J Surg 1989 Feb;157(2):264-71.
- 12.First MR, Schroeder TJ, Weiskittel P, Myre SA, Alexander JW, Pesce AJ. Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients. Lancet 1989 Nov 18;2(8673):1198-201.
- 13.Frey FJ. Concomitant cyclosporin and ketoconazole. Lancet 1990 Jan 13; 335(8681):109-10.
- 14.Ah-Sing E, Poole TW, Ioannides C, King LJ. Mechanism of the ketoconazole-cyclosporin interaction. Arch Toxicol 1990;64(6):511-3.
- 15.Katzir D, Balschke TF. The cyclosporine-ketoconazole interaction. Hosp Ther 1990 Jan;15:99-112.
- 16.First MR, Schroeder TJ, Alexander JW, Stephens GW, Weiskittel P, Myre SA, Pesce AJ. Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients. Transplantation 1991 Feb;51(2):365-70.
- 17.Albengres E, Tillement JP. Cyclosporin and ketoconazole, drug interaction or therapeutic association?. Int J Clin Pharmacol Ther Toxicol 1992 Dec; 30(12):555-70.
- 18.First MR, Schroeder TJ, Michael A, Hariharan S, Weiskittel P, Alexander JW. Cyclosporine-ketoconazole interaction. Long-term follow-up and preliminary results of a randomized trial. Transplantation 1993 May; 55(5):1000-4.
- 19.Sadaba B, Campanero MA, Quetglas EG, Azanza JR. Clinical relevance of sirolimus drug interactions in transplant patients. Transplant Proc 2004 Dec;36(10):3226-8.
- 20.Thomas PP, Manivannan J, John GT, Jacob CK. Sirolimus and ketoconazole co-prescription in renal transplant recipients. Transplantation 2004 Feb 15;77(3):474-5.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.