Tacrolimus (Extended Release)/Alcohol Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your medication is designed to release tacrolimus slowly. Alcohol may cause your tacrolimus to be released too quickly.
What might happen:
The amount of medicine in your blood may increase and may put you at an increased risk for side effects such as an irregular heartbeat, which can be life-threatening.
What you should do about this interaction:
Avoid alcohol or liquid medicines which contain alcohol when using this medicine because it may cause the medication to be released too quickly and result in an increased risk of side effects. Contact your health care provider (e.g. doctor or pharmacist) if you have questions.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Astagraf XL (tacrolimus extended-release capsules) US prescribing information. Astellas Pharma US, Inc. August, 2023.
- 2.Envarsus XR (tarolimus extended-release tablets) US prescribing information. Veloxis Pharmaceuticals September, 2023.
- 3.US Food and Drug Administration (FDA). Drug Approval Package Astagraf XL (tacrolimus extended-release capsules) Application No.: 204096. Accessed at: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/204096Orig1s000Cli nPharmR.pdf July 19, 2013.
- 4.US Food and Drug Administration (FDA). Drug Approval Package Envarsus XR (tacrolimus extended-release tablets) Application No.: 206406Orig1. Accessed at: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/206406Orig1s000Cli nPharmR.pdf July 10, 2015.
- 5.Tanzi MG, Undre N, Keirns J, Fitzsimmons WE, Brown M, First MR. Pharmacokinetics of prolonged-release tacrolimus and implications for use in solid organ transplant recipients. Clin Transplant 2016 Aug; 30(8):901-11.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.