Vitamin A/Selected Retinoids Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Retinoids and vitamin A are in the same family of chemicals.

What might happen:

If you take vitamin A supplements with your retinoid, you may be getting too much vitamin A in your system.

What you should do about this interaction:

If you are taking acitretin, do not take more vitamin A than the minimum recommended daily allowance (USRDA) without discussing it with your healthcare professional (e.g. doctor or pharmacist.)If you are taking bexarotene, your doctor may want you to limit your vitamin A intake. Before starting a vitamin A supplement, discuss it with your healthcare professional.If you are taking alitretinoin, isotretinoin, palovarotene or tretinoin, your doctor may not want you to take any vitamin A supplements. Before starting a vitamin A supplement, discuss it with your healthcare professional.If you do take a vitamin A supplement with your retinoid, let your doctor know if you experience any nausea, vomiting, loss of appetite, weakness, dry or itchy skin or lips, irritability, or hair loss. These could be signs that you have too much vitamin A in your system.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Soriatane (acitretin) US prescribing information. Roche Pharmaceuticals February, 2014.
  • 2.Targretin (bexarotene) Capsules US prescribing information. Valeant Pharmaceuticals North America LLC July, 2015.
  • 3.Accutane (isotretinoin) US prescribing information. Roche Laboratories, Inc. January, 2010.
  • 4.Sohonos (palovarotene) Canadian Product Monograph. Ipsen Biopharmaceuticals Canada Inc. January, 2022.
  • 5.Vesanoid (tretinoin) US prescribing information. Roche Laboratories, Inc. February, 2023.
  • 6.Toctino (alitretinoin) UK summary of product characteristics. Basilea Pharmaceuticals Ltd September 19, 2008.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.