Ticagrelor/High-Dose Aspirin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

How this interaction occurs is not known.

What might happen:

Ticagrelor and aspirin are used together. However, taking extra or higher than recommended aspirin doses may cause in your ticagrelor not work as well.

What you should do about this interaction:

Most patients do take aspirin with ticagrelor; however, after an initial 325 mg dose, the daily aspirin dose usually should not exceed 100 mg for most patients.Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together and how much you are taking. To maximize the benefit and safety of ticagrelor, do not take additional aspirin or combination medications which contain aspirin for fever, pain or other conditions unrelated to your heart or circulation. Ask your doctor or pharmacist to recommend alternative medicines for these conditions.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Brilinta (ticagrelor) US prescribing information. AstraZeneca LP November, 2020.
  • 2.Brilique (ticagrelor) UK summary of product characteristics. AstraZeneca UK Limited October 24, 2012.
  • 3.Brilinta (ticagrelor) Canada prescribing information. AstraZeneca Canada May 26, 2011.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.