Pemetrexed/Aspirin (Greater Than 81 mg and Less Than or Equal To 325 mg) Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Higher doses of aspirin may prevent your kidneys from removing pemetrexed from your body.

What might happen:

The amount of pemetrexed in your body may increase and cause more side effects than normally expected.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking aspirin, especially if you are taking more than 4 tablets per day. Depending upon your aspirin dose, your doctor may want you to stop taking your aspirin for a few days before and a few days after your pemetrexed treatment.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Alimta (pemetrexed for injection) US prescribing information. Eli Lilly and Company June, 2018.
  • 2.Personal Communication: Alimta - Use with nsaids or aspirin. Eli Lilly and Company February 10, 2004.
  • 3.Sweeney CJ, Takimoto CH, Latz JE, Baker SD, Murry DJ, Krull JH, Fife K, Battiato L, Cleverly A, Chaudhary AK, Chaudhuri T, Sandler A, Mita AC, Rowinsky EK. Two drug interaction studies evaluating the pharmacokinetics and toxicity of pemetrexed when coadministered with aspirin or Ibuprofen in patients with advanced cancer. Clin Cancer Res 2006 Jan 15; 12(2):536-42.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.