Who should not take Ponatinib Tablet?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:

Conditions:

  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • pancreatitis
  • a rupture in the wall of the stomach or intestine
  • a patient who is producing milk and breastfeeding
  • visible water retention
  • pregnancy
  • impaired wound healing
  • abnormal liver function tests
  • recent operation
  • bleeding
  • peripheral vascular disease
  • obstruction of a blood vessel by a blood clot
  • bleeding within the skull
  • hepatitis B
  • supraventricular arrhythmias
  • a type of abnormal heart rhythm
  • slow heartbeat
  • eye symptoms or problems
  • low levels of a type of white blood cell called neutrophils
  • decreased blood platelets
  • anemia
  • high blood pressure
  • a heart attack
  • coronary artery disease
  • sudden and serious symptoms of heart failure called acute decompensated heart failure
  • a stroke
  • blood clot formation in vein
  • blockage or closing off of blood vessels
  • acute blood clot in the heart
  • chronic heart failure
  • a localized weakening and ballooning in an artery wall called an arterial aneurysm
  • a blood clot in an artery
  • dissection of artery
  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.