Vadadustat/Polyvalent Cations and Phosphate Binders Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Medicines containing aluminum, calcium, iron, magnesium, selenium, and zinc may bind to vadadustat in your digestive tract.

What might happen:

Your body may not absorb as much vadadustat. Vadadustat may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Time your medicines so that you do not take your vadadustat one hour before or two hours after any medicine containing aluminum, calcium, iron, magnesium, selenium, or zinc.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Vafseo (vadadustat) Australian prescribing information. Akebia Therapeutics, Inc. October, 2023.
  • 2.Paulson SK, Martinez J, Sawant R, Burke SK, Chavan A. Effect of Phosphate Binders and a Dietary Iron Supplement on the Pharmacokinetics of a Single Dose of Vadadustat in Healthy Adults. Clinical Pharmacology in Drug Development 19 September 2021;11(4):475-485.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.