Dolutegravir/Etravirine; Efavirenz; Nevirapine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Etravirine, efavirenz, and nevirapine may speed up how quickly your body processes dolutegravir.
What might happen:
The blood levels of your dolutegravir may be decreased, which will decrease its effectiveness.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have a history of resistance to any HIV medicine. Your doctor may need to change the dose of your dolutegravir, change the protease inhibitor you are taking, or change your NNRTI.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Tivicay (dolutegravir) US prescribing information. GlaxoSmithKline October, 2022.
- 2.Triumeq (abacavir-dolutegravir-lamivudine) US prescribing information. Viiv Healthcare June, 2023.
- 3.Tivicay (dolutegravir sodium) UK summary of product characteristics. ViiV Healthcare UK Ltd January, 2021.
- 4.Tivicay (dolutegravir) Canadian prescribing information. ViiV Healthcare ULC August, 2018.
- 5.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents Living with HIV. Department of Health and Human Services. Available at https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv/whats- new-guidelines June 13, 2021.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.