Cilostazol (Less Than or Equal To 50 mg)/Strong & Moderate CYP2C19 Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process cilostazol properly. Also, both medicines can affect your heart's rhythm.

What might happen:

Your blood levels of cilostazol may increase and cause harmful effects. Taking these medicines together may also increase your risk of an irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

Contact your doctor if you experience headache; diarrhea; dizziness; or bloating or swelling of the ankles, feet, or hands. The dose of your medicines may need adjusting. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Pletal (cilostazol) US prescribing information. Otsuka America Pharmaceutical, Inc. January, 2015.
  • 2.Nexium (esomeprazole magnesium) US prescribing information. AstraZeneca Pharmaceuticals LP August, 2021.
  • 3.Prilosec (omeprazole) US prescribing information. AstraZeneca Pharmaceuticals LP June, 2018.
  • 4.Suri A, Bramer SL. Effect of omeprazole on the metabolism of cilostazol. Clin Pharmacokinet 1999;37 Suppl 2:53-9.
  • 5.USDepartment of Health and Human Services Food and Drug Administration. ICH E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs. Available at: https://www.fda.gov/media/71372/download October, 2005.
  • 6.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.