Oral Midazolam/Selected CYP3A4 Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Boceprevir, cobicistat, and telaprevir may slow down how quickly your liver processes midazolam.
What might happen:
Your blood levels of midazolam may increase and cause harmful effects.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Contact your doctor if you experience decreased coordination, excessive drowsiness, confusion, slurred speech, or difficulty breathing.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Victrelis (boceprevir) US prescribing information. Schering Corporation January, 2017.
- 2.Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir) US prescribing information. Gilead Sciences, Inc. September, 2021.
- 3.Zydelig (idelalisib) US prescribing information. Gilead Sciences, Inc. October, 2020.
- 4.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.
- 5.Garg V, Chandorkar G, Farmer HF, Smith F, Alves K, van Heeswijk RP. Effect of Telaprevir on the Pharmacokinetics of Midazolam and Digoxin. J Clin Pharmacol 2012 Jan 26.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.