Bromocriptine; Cabergoline/Selected CYP3A4 Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process bromocriptine or cabergoline properly.

What might happen:

Your blood levels of your bromocriptine or cabergoline may increase and may cause increased side effects.

What you should do about this interaction:

Contact your healthcare professional (e.g. doctor or pharmacist) right away about using these medicines together. Your doctor may not want you to take bromocriptine or cabergoline while you are taking your antifungal.If you experience nausea, constipation, loss of appetite, dry mouth, vomiting, abnormal involuntary movements, headache, dizziness, weakness, or fatigue contact your healthcare professional.Your healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference
  • 1.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. February, 2024.
  • 2.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
  • 3.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. January, 2022.
  • 4.Noxafil (posaconazole) US prescribing information. Merck & Co. Inc January, 2022.
  • 5.Vfend (voriconazole) US prescribing information. Pfizer Inc. October, 2022.
  • 6.Christensen J, Dupont E, OStergaard K. Cabergoline plasma concentration is increased during concomitant treatment with itraconazole. Mov Disord 2002 Nov;17(6):1360-2.
  • 7.Agenerase (amprenavir) Oral Solution US prescribing information. GlaxoSmithKline May, 2005.
  • 8.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company November, 2023.
  • 9.Victrelis (boceprevir) US prescribing information. Schering Corporation January, 2017.
  • 10.Prezista (darunavir) US prescribing information. Janssen Therapeutics March, 2023.
  • 11.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline March, 2019.
  • 12.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. September, 2016.
  • 13.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories December, 2019.
  • 14.Viracept (nelfinavir mesylate) US prescribing information. Agouron Pharmaceuticals, Inc. September, 2016.
  • 15.Paxlovid (nirmatrelvir tablets and ritonavir tablets) US prescribing information. Pfizer Inc. May, 2023.
  • 16.Norvir (ritonavir) US prescribing information. Abbott Laboratories December, 2019.
  • 17.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. March, 2019.
  • 18.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.
  • 19.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. June, 2020.
  • 20.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.