Suvorexant/Lonafarnib Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process suvorexant or lonafarnib properly.
What might happen:
Your blood levels of suvorexant and lonafarnib may increase and cause harmful effects, including confusion, memory loss, sleep-walking, daytime drowsiness, nausea and vomiting, increased risk of infection, high blood pressure, and increased liver enzymes.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Call you doctor as soon as possible if you have confusion/not thinking clearly, memory loss, daytime drowsiness, or have been told you were sleep-walking or doing other activities when you are asleep. Your doctor may want to change or alter the dose of your sleeping pill. Use caution and know how these medicines affect you before driving or operating machinery.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Belsomra (suvorexant) US prescribing information. Merck & Co., Inc. March, 2021.
- 2.Zokinvy (lonafarnib) US prescribing information. Eiger BioPharmaceuticals, Inc. November, 2020.
- 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 4.Becquemont L, Mouajjah S, Escaffre O, Beaune P, Funck-Brentano C, Jaillon P. Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism. Drug Metab Dispos 1999 Sep;27(9):1068-73.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.