Opdivo Vial Side Effects by Likelihood and Severity

COMMON side effects


If experienced, these tend to have a Severe expression

  • A High Alanine Transaminase Level
  • A High Aspartate Transaminase Level
  • Abnormal Liver Function Tests
  • High Levels Of Potassium In The Blood
  • Inflammation Of The Large Intestine
  • Low Amount Of Magnesium In The Blood
  • Low Amount Of Potassium In The Blood
  • Low Levels Of A Type Of White Blood Cell Called Neutrophils
  • Thyroid Gland Inflammation

If experienced, these tend to have a Less Severe expression

  • A Common Cold
  • A Skin Rash
  • Backache
  • Constipation
  • Cough
  • Decreased Appetite
  • Diarrhea
  • Fever
  • Fluid Retention In The Legs, Feet, Arms Or Hands
  • Generalized Weakness
  • Headache
  • High Blood Levels Of The Lipase Enzyme
  • Intense Abdominal Pain
  • Itching
  • Joint Pain
  • Low Amount Of Sodium In The Blood
  • Low Energy
  • Nausea
  • Pain In The Muscles Or Bones
  • Trouble Breathing
  • Vomiting

INFREQUENT side effects


If experienced, these tend to have a Severe expression

  • A Clot In The Lung
  • A Hypersensitivity Reaction To A Drug
  • A Systemic Inflammatory Response Called Sepsis Due To An Infection With Bacteria
  • A Type Of Inflammation Of The Lung Called Interstitial Pneumonitis
  • An Abnormal Connection Between The Esophagus And Windpipe
  • Bleeding Of The Stomach Or Intestines
  • Decreased Function Of The Adrenal Gland
  • Decreased Kidney Function
  • Demyelinating Disorder
  • Escape Of Fluid Into The Lungs
  • High Amount Of Bilirubin In The Blood
  • Liver Inflammation Resulting From An Abnormal Immune Response
  • Lung Failure Causing Loss Of Breath
  • Lung Tissue Problem
  • Pneumonia

If experienced, these tend to have a Less Severe expression

  • A Condition Where Portions Of The Skin Lose The Natural Color Called Vitiligo
  • A Condition With Low Thyroid Hormone Levels
  • Bronchitis
  • Chills
  • Difficulty Swallowing
  • Dizziness
  • Dry Eye
  • Fast Heartbeat
  • High Blood Sugar
  • Muscle Weakness
  • Overactive Thyroid Gland
  • Peripheral Sensory Nerve Disorder
  • Temporary Redness Of Face And Neck
  • Visible Water Retention
  • Weight Loss

RARE side effects


If experienced, these tend to have a Severe expression

  • A Complication Of Diabetes With High Blood Ketone Levels Called Diabetic Ketoacidosis
  • A Condition With Dry Eyes, Dry Mouth And Arthritis Called Sjogren's Syndrome
  • A Condition With Muscle Tissue Breakdown Called Rhabdomyolysis
  • A Disease With Shrinking And Weaker Muscles Called Myopathy
  • A Facial Nerve Disorder
  • A Rupture In The Wall Of The Stomach Or Intestine
  • A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
  • A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis
  • A Type Of Blood Disorder Where The Red Blood Cells Burst Called Hemolytic Anemia
  • A Type Of Kidney Inflammation Called Interstitial Nephritis
  • Acidosis, A High Level Of Acid In The Blood
  • An Ulcer Of The Duodenum
  • An Unusual Viral Infection Called Cytomegalovirus Infection
  • Anemia
  • Atrial Fibrillation
  • Bleeding From The Lungs
  • Cytokine Release Syndrome, A Sudden Activation Of The Immune System
  • Destruction Of Red Blood Cells By Body's Own Antibodies
  • Diabetes
  • Encephalitis
  • Erythema Multiforme, A Type Of Allergic Skin Reaction
  • Erythrodysesthesia Or Tingling, Pain, Redness, And Edema In The Hands And Feet
  • Graft-Versus-Host Disease
  • Guillain-Barre Syndrome
  • Hemophagocytic Lymphohistiocytosis, A Condition Where The Body Makes Too Many Activated Immune Cells
  • High Blood Pressure
  • Histiocytic Necrotizing Lymphadenitis, A Condition With Swollen Glands In The Neck And Flu Symptoms
  • Increased Eosinophils In The Blood
  • Inflammation Of The Blood Vessels
  • Inflammation Of The Covering Of The Heart Or Pericardium
  • Inflammation Of The Duodenum
  • Inflammation Of The Iris And Ciliary Body Of The Eye
  • Inflammation Of The Liver Called Hepatitis
  • Inflammation Of The Middle Tissue Heart Muscle
  • Inflammation Of The Pituitary Gland
  • Inflammation Of The Uvea Of The Eye
  • Kidney Failure
  • Low Blood Counts Due To Bone Marrow Failure
  • Low Platelet Count And Bleeding From Immune Response
  • Muscle Inflammation
  • Muscle Pain And Stiffness In The Shoulder, Neck And Pelvis
  • Osteoarthritis Of The Spine
  • Pancreatitis
  • Pituitary Hormone Deficiency
  • Progressive Muscle Weakness With Carcinoma
  • Rejection Of A Transplanted Organ
  • Sarcoidosis
  • Sepsis
  • Skin Rash With Sloughing
  • Tumor Lysis Syndrome
  • Ventricular Arrhythmias, A Type Of Abnormal Heart Rhythm
  • Vogt-Koyanagi-Harada Disease, An Inflammatory Disease Of Certain Cells Of The Eyes, Ears And Skin

If experienced, these tend to have a Less Severe expression

  • A Disorder Of The Peripheral Nerves That Enable Movement Called Peripheral Motor Neuropathy
  • A Type Of Stomach Irritation Called Gastritis
  • Arthritis
  • Dehydration
  • High Blood Levels Of The Amylase Enzyme
  • Kidney Inflammation
  • Peripheral Nerve Inflammation
  • Psoriasis
  • Stomatitis, A Condition With Painful Swelling And Sores Inside The Mouth

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.