Antifibrinolytics/Factor IX; Anti-Inhibitor Coagulant Conc Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines increase your body's ability to form blood clots.
What might happen:
Using these medicines together may increase your risk of forming an unwanted blood clot.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Amicar (aminocaproic acid) US prescribing information. Clover Pharms August, 2008.
- 2.Cyklokapron (tranexamic acid) US prescribing information. Pharmacia Corporation February, 2021.
- 3.Lysteda (tranexamic acid) US prescribing information. Ferring Pharmaceuticals, Inc. October, 2013.
- 4.Djulbegovic B, Marasa M, Pesto A, Kushner GM, Hadley T, Joseph G, Goldsmith G. Safety and efficacy of purified factor IX concentrate and antifibrinolytic agents for dental extractions in hemophilia B. Am J Hematol 1996 Feb;51(2):168-70.
- 5.Holmstrom M, Tran HT, Holme PA. Combined treatment with APCC (FEIBA(R)) and tranexamic acid in patients with haemophilia A with inhibitors and in patients with acquired haemophilia A--a two-centre experience. Haemophilia 2012 Jul;18(4):544-9.
- 6.Tran HT, Sorensen B, Rea CJ, Bjornsen S, Ueland T, Pripp AH, Tjonnfjord GE, Holme PA. Tranexamic acid as adjunct therapy to bypassing agents in haemophilia A patients with inhibitors. Haemophilia 2014 May; 20(3):369-75.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.