Selected Protease Inhibitors; Cobicistat/Oxcarbazepine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Oxcarbazepine may speed up how quickly your body processes your HIV medicine.
What might happen:
Your HIV medicine may not work as well or cause more side effects than expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company November, 2023.
- 2.Evotaz (atazanavir and cobicistat) US prescribing information. Bristol-Myers-Squibb Company May, 2023.
- 3.Tybost (cobicistat) US prescribing information. Gilead Sciences, Inc. September, 2021.
- 4.Prezista (darunavir) US prescribing information. Janssen Therapeutics March, 2023.
- 5.Symtuza (darunavir, cobicistat, emtricitabine, tenofovir alafenamide) US prescribing information. Janssen Pharmaceutical Companies April, 2022.
- 6.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories December, 2019.
- 7.Trileptal (oxcarbazepine) US prescribing information. Novartis Pharmaceuticals Corporation November, 2017.
- 8.Oxtellar XR (oxcarbazepine) extended-release US prescribing information. Supernus, Inc. December, 2018.
- 9.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 10.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents Living with HIV. Department of Health and Human Services. Available at: https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult- and-adolescent-arv/whats-new March 23, 2023.
- 11.Liverpool Drug Interactions Group. HIV Drug Interactions. Available at: https://hiv-druginteractions.org/.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.