Rosuvastatin/Clopidogrel Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Clopidogrel may slow down how quickly your body processes rosuvastatin.
What might happen:
The amount of rosuvastatin in your blood may increase and may cause harmful effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any unexplained muscle pain, tenderness, weakness, or discoloration of your urine. Your doctor may want to change your cholesterol medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Elsby R, Martin P, Surry D, Sharma P, Fenner K. Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure. Drug Metab Dispos 2016 Mar; 44(3):398-408.
- 2.Ning C, Su S, Li J, Kong D, Cai H, Qin Z, Xing H, Chen X, He J. Evaluation of a Clinically Relevant Drug-Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity. Front Pharmacol 2021; 12:715577.
- 3.Pinheiro LF, Franca CN, Izar MC, Barbosa SP, Bianco HT, Kasmas SH, Mendes GD, Povoa RM, Fonseca FA. Pharmacokinetic interactions between clopidogrel and rosuvastatin: effects on vascular protection in subjects with coronary heart disease. Int J Cardiol 2012 Jun 28;158(1):125-9.
- 4.Plavix (clopidogrel) Canadian Product Monograph. sanofi-aventis Canada Inc. February, 2022.
- 5.Plavix (clopidogrel hydrogen sulfate) Australian prescribing information. Sanofi-Synthelabo Australia Pty Limited May, 2022.
- 6.Plavix (clopidogrel bisulfate) US prescribing information. Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership September, 2022.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.