Glyburide/Safinamide Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Safinamide may increase the amount of glyburide your body absorbs and may also cause your blood sugar to be too low.
What might happen:
Your blood sugar levels may decrease and cause harmful effects.
What you should do about this interaction:
If you experience a sudden onset of cold sweat, dizziness, fatigue, shakiness, rapid heartbeat, nausea, vision changes, confusion, personality change, nervousness, or hunger, contact your doctor. It may be necessary to measure your blood sugar levels more often. Your doctor may need to adjust the dose of your diabetes medicine. The full effects of this interaction may take several weeks to appear and may last for several weeks after you stop taking your other medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Xadago (safinamide) EMA summary of product characteristics. Zambon S.p.A. October 30, 2019.
- 2.Xadago (safinamide) US prescribing information. US WorldMeds, LLC August, 2021.
- 3.European Medicines Agency (EMA). Xadago: EPAR - Procedural steps taken and scientific information after the authorisation. Accessed at: https://www.ema.europa.eu/en/documents/procedural-steps-after/xadago-epar- procedural-steps-taken-scientific-information-after-authorisation_en.pdf October 30, 2019.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.