Infigratinib; Selpercatinib/Antacids Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The pH of your GI tract needs to be acidic for your cancer medicine to dissolve and be absorbed. Antacids change the pH (acidity) of your GI tract.Some vitamins may contain "hidden" antacids such as some forms of calcium and magnesium.

What might happen:

Taking your cancer medicine at the same time as an antacid may decrease the amount of medicine in your blood, and your cancer medicine may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine.If you need to use an antacid, take your cancer medicine at least 2 hours before or 2 hours after the antacid.If your doctor changes the antacid to an H2 blocker, take your cancer medicine at least 2 hours before or 10 hours after the H2 blocker.If your doctor changes the antacid to a proton pump inhibitor, take selpercatinib with food.If you have questions about how to schedule your medicines, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Truseltiq (infigratinib) US prescribing information. QED Therapeutics, Inc. May, 2021.
  • 2.Retevmo (selpercatinib) US prescribing information. Eli Lilly April, 2024.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.