Mitotane/Spironolactone Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known.
What might happen:
When these two medicines are taken together, spironolactone may decrease the amount of mitotane in your body.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. Your doctor may want to change your medicines or monitor you more closely.Your doctor may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with your doctor.
- 1.Lysodren (mitotane) US prescribing information. E.R. Squibb & Sons, L.L.C. January, 2024.
- 2.Haberbosch L, Maurer L, Sandforth A, Wernicke C, Spranger J, Mai K, Jumpertz von Schwartzenberg R. Spironolactone is associated with reduced mitotane levels in adrenocortical carcinoma patients. Endocr Relat Cancer 2022 Feb 3;29(3):121-128.
- 3.Wortsman J, Soler NG. Mitotane. Spironolactone antagonism in Cushing's syndrome. JAMA 1977 Dec 5;238(23):2527.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.