Atazanavir/Tenofovir disoproxil Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Tenofovir disoproxil may speed up how quickly your body processes atazanavir. It is not known how atazanavir increases tenofovir disoproxil levels.
What might happen:
Your the amount of atazanavir in your blood may decrease and it may not work as well against your HIV infection. The amount of tenofovir disoproxil in your blood may increase and cause more side effects than normal.
What you should do about this interaction:
To prevent low levels of atazanavir, your doctor may give you a low dose of ritonavir to taken with your medicines. If you are not taking ritonavir, discuss it with your healthcare professional (e.g. doctor or pharmacist.)Let your doctor know right away if you have any of the following symptoms, which may be from your tenofovir disoproxil: weakness, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, feeling of cold - especially in the arms and legs, dizziness, lightheadedness, fast/irregular heartbeat, yellowing of the eyes/skin, dark urine, light colored stools, or loss of appetite.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company November, 2023.
- 2.Truvada (emtricitabine/tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. June, 2020.
- 3.Viread (tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. December, 2018.
- 4.Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. October, 2019.
- 5.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents Living with HIV. Department of Health and Human Services. Available at https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv/whats- new-guidelines June 13, 2021.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.