Penicillamine, Oral/Iron Salts, Oral Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, iron may tie up the penicillamine in your stomach. This reduces the amount of penicillamine that is absorbed by your body.

What might happen:

The penicillamine may not work as well as it would if you were taking it alone.

What you should do about this interaction:

If you notice your medical condition worsening or other unusual effects, contact your healthcare professional (e.g. doctor or pharmacist.) It may be necessary to adjust the dose of your medicines or change the time when you take them.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Lyle WH. Penicillamine and iron. Lancet 1976 Aug 21;2(7982):420.
  • 2.Osman MA, Patel RB, Schuna A, Sundstrom WR, Welling PG. Reduction in oral penicillamine absorption by food, antacid, and ferrous sulfate. Clin Pharmacol Ther 1983 Apr;33(4):465-70.
  • 3.Muijsers AO, van de Stadt RJ, Henrichs AM, Ament HJ, van der Korst JK. D-penicillamine in patients with rheumatoid arthritis. Serum levels, pharmacokinetic aspects, and correlation with clinical course and side effects. Arthritis Rheum 1984 Dec;27(12):1362-9.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.